Frequently Asked Questions

General Questions

What is a Red Cell Therapeutic?

A Red Cell Therapeutic is a red blood cell that has been genetically engineered into a medicine for the potential treatment of cancer.

How is a Red Cell Therapeutic made?

Red blood cells are continuously replenished by the body from precursor cells in the bone marrow to maintain healthy levels in circulation.
Rubius Therapeutics uses these precursor cells to create its Red Cell Therapeutics.
These precursor cells are collected from healthy O-negative blood donors and are purified.

To turn these precursor cells into medicines, Rubius Therapeutics uses a process called genetic engineering to insert an extra gene or genes encoding therapeutic proteins into the cell.
The precursor cells are then placed into cell culturing tanks, where they grow and turn into red blood cells.
As the last step in the process, the cells lose their nucleus, leaving the therapeutic protein in or on the red blood cell.

How is a Red Cell Therapeutic given to a patient?

Red Cell Therapeutics are administered via a short infusion into a vein and infusion time will vary, depending on the dose level.

In what treatment setting is a patient given a Red Cell Therapeutic (e.g. doctor’s office, transfusion center)?

The Red Cell Therapeutic will be given at the clinical trial center.

How do I know the donor’s cells used to make Red Cell Therapeutics is safe?

The cell supply that Rubius Therapeutics uses to create Red Cell Therapeutics is rigorously tested for safety and quality and comes from certified centers that meet federal safety standards.
Donors are screened for infectious diseases and the blood is tested for any infections, similar to other blood-based products.
Before administration of any of our RCT product candidates, cross-matching tests will be performed to ensure the compatibility of the product to the patient.

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