Frequently Asked Questions

General Questions

What is a Red Cell Therapeutic?

A Red Cell Therapeutic is a red blood cell that has been genetically engineered into a medicine for the potential treatment of cancer and autoimmune diseases.

How is a Red Cell Therapeutic made?

Red blood cells (RBC’s) live for approximately 120 days and are continuously replenished by the body to maintain healthy levels in circulation.
RBC’s are replenished from immature precursor cells in the bone marrow. Rubius uses these immature precursor cells to create its Red Cell Therapeutics.
These immature precursor cells are collected from healthy O-negative blood donors and are purified.
To turn these immature cells into medicines, Rubius uses a process called genetic engineering to insert an extra gene or genes into the cell.

This gene makes a therapeutic protein used to potentially treat the intended disease.
The cells are then placed into cell culturing tanks, where they grow and turn into red blood cells.
As the last step in the process, the cells lose their nucleus, leaving the therapeutic protein in or on the red cell
Except for the therapeutic protein, the red blood cells appear to be just like red blood cells made in our bodies.

How is a Red Cell Therapeutic given to a patient?

Red Cell Therapeutics are administered via a short infusion into a vein and infusion time will vary, depending on the dose level.

In what treatment setting is a patient given a Red Cell Therapeutic (e.g. doctor’s office, transfusion center)?

The Red Cell Therapeutic will be given at the clinical trial center.

How do I know the donor’s cells used to make Red Cell Therapeutics is safe?

The cell supply that Rubius Therapeutics uses to create Red Cell Therapeutics is rigorously tested for safety and quality and comes from certified centers that meet federal safety standards.
Donors are screened for infectious diseases and the blood is tested for any infections, similar to other blood-based products.
Before administration of any of our RCT product candidates, cross-matching tests will be performed to ensure the compatibility of the product to the patient.

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